[430g] - Evaluation of operational process parameters for nanoparticle precipitation in microemulsions using a Monte-Carlo Simulation approach

A Monte-Carlo simulation approach for the nanoparticle precipitation in microemulsions has been developed and adapted to nanoparticle precipitation. The simulation includes especially technical process parameters like feed rate, initial volume ratio or molar ratio of initial reactant concentrations. A set of experiments with different initial reactant concentrations of and is compared to the simulated final particle size. An adaptation of certain internal parameters of the Monte-Carlo simulation leads to a good agreement between simulated and experimental data. The same internal parameters are then used for other variations of the technical process conditions like the feeding rate or initial volume ratio. It is shown how those process parameters influence the particle size and the size distribution. The simulation results help in finding appropriate control parameters in an up-scale approach of the microemulsion technology for nanoparticle production.